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Article

Recovery of CYP3A Phenotype after Kidney Transplantation.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2017

Hole Kristine, Størset Elisabet, Olastuen Ane, Haslemo Tore, Kro Grete Birkeland, Midtvedt Karsten, Åsberg Anders, Molden Espen

Abstract excerpt

End-stage renal disease impairs drug metabolism via cytochrome P450 CYP3A; however, it is unclear whether CYP3A activity recovers after kidney transplantation. Therefore, the aim of this study was to evaluate the change in CYP3A activity measured as 4β-hydroxycholesterol (4βOHC) concentration after kidney transplantation. In total, data from 58 renal transplant recipients with 550 prospective 4βOHC measurements...

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Identifiers

PMID: 28928137
DOI: 10.1124/dmd.117.078030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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