Article
Association of plasma concentration of 4β-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2014
Suzuki Yosuke, Itoh Hiroki, Fujioka Takashi, Sato Fuminori, Kawasaki Kanako, Sato Yukie, Sato Yuhki, Ohno Keiko, Mimata Hiromitsu, Kishino Satoshi
Abstract excerpt
Several studies have shown that renal failure decreases CYP3A activity and that uremic toxins may play a role via transcriptional or translational modifications of cytochrome P450 (P450) enzymes and direct inhibition of P450-mediated metabolism. In this study, we evaluated the relationship between CYP3A activity (using plasma concentration of 4β-hydroxycholesterol as a biomarker) and clinical characteristics...
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