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Article

Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease.

Clinical pharmacology and therapeutics - 1 May 2003

Dowling Thomas C, Briglia Andrew E, Fink Jeffrey C, Hanes Donna S, Light Paul D, Stackiewicz Lucy, Karyekar Chetan S, Eddington Natalie D, Weir Matthew R, Henrich William L

Abstract excerpt

BACKGROUND: The cytochrome p450 (CYP) oxidative enzyme system, located primarily in the liver and small intestine, is responsible for metabolism and detoxification of numerous endogenous and exogenous substances. The most abundant CYP enzyme, CYP3A, is known to be involved in the metabolism of more than 200 commonly used medications. In experimental models of renal failure, both hepatic function and CYP enzyme...

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Source

Identifiers

PMID: 12732843
DOI: 10.1016/s0009-9236(03)00056-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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