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Article

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

Vascular pharmacology - 1 Dec 2017

Wadey K S, Brown B A, Sala-Newby G B, Jayaraman P-S, Gaston K, George S J

Abstract excerpt

Neointimal hyperplasia is a product of VSMC replication and consequent accumulation within the blood vessel wall. In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH) could suppress VSMC proliferation. Both silencing and pharmacological inhibition of CK2 with K66 antagonised replication of isolated VSMCs. SiRNA-induced knockdown as...

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Source

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Identifiers

PMID: 28927755
DOI: 10.1016/j.vph.2017.09.004
PMCID: PMC5718878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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