Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cks1 mediates vascular smooth muscle cell polyploidization.

The Journal of biological chemistry - 22 Dec 2000

Hixon M L, Obejero-Paz C, Muro-Cacho C, Wagner M W, Millie E, Nagy J, Hassold T J, Gualberto A

Abstract excerpt

Vascular smooth muscle cells (VSMC) at capacitance arteries of hypertensive individuals and animals undergo dramatic polyploidization that contributes toward their hypertrophic phenotype. We report here the identification of a defective mitotic spindle cell cycle checkpoint in VSMC isolated from capacitance arteries of pre-hypertensive rats. These cells demonstrated a high predisposition to polyploidization in...

Topics

Animals
Cyclin-Dependent Kinases
Muscle, Smooth, Vascular
Phenotype
Polyploidy
Rats
Rats, Inbred SHR
Rats, Inbred WKY

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11005810
DOI: 10.1074/jbc.M005059200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cks1 mediates vascular smooth muscle cell polyploidization.PMID 11005810Read ↗

MARCKS silencing differentially affects human vascular smooth muscle and endothelial cell phenotypes to inhibit neointimal hyperplasia in saphenous vein.Semantic proximity Read ↗

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.Semantic proximity Read ↗

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells.Semantic proximity Read ↗

Cell cycle–dependent centrosome clustering precedes proplatelet formationSemantic proximity Read ↗

Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content.Semantic proximity Read ↗

Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferaseSemantic proximity Read ↗

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.Semantic proximity Read ↗

Cell Cycle in Vasculoproliferative DiseasesSemantic proximity Read ↗

Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway.Semantic proximity Read ↗

Accelerated entry of aortic smooth muscle cells from spontaneously hypertensive rats into the S phase of the cell cycle.Semantic proximity Read ↗

Characterization of molecular determinants of smooth muscle cell heterogeneity.Semantic proximity Read ↗

Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.