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Article

A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer.

Cancer causes & control : CCC - 1 Mar 2009

Nan Hongmei, Qureshi Abrar A, Hunter David J, Han Jiali

Abstract excerpt

The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator Sp1 for the MDM2 gene promoter, resulting in higher expression of MDM2 and thus inhibition of p53 transcriptional activity. UV-induced p53 activation promotes cutaneous transient pigmentation, and the common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 18814047
DOI: 10.1007/s10552-008-9231-9
PMCID: PMC2631619

Genes

MDM2
NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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