Article

Insights into fucose metabolism: SLC35C1-independent fucosylation discriminates against mannose-derived GDP-fucose

2021-11-23

Abstract excerpt

<title>Abstract</title> <p>Mutations in the <italic>SLC35C1</italic> gene, encoding the Golgi GDP-fucose transporter, cause leukocyte adhesion deficiency II (LADII). Fucosylation improvement in LADII patients treated with fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which still remains a mystery. Here, we developed and characterized a human cell-based model deficient in t...

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Literature Corpus work: 6b3726f5-a40f-5417-bc0f-8ffe3c439d37
DOI: 10.21203/rs.3.rs-1096518/v1

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