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Article

Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells.

The Journal of biological chemistry - 12 Nov 2010

Lu Linchao, Hou Xinghua, Shi Shaolin, Körner Christian, Stanley Pamela

Abstract excerpt

Mammalian Notch receptors require modification by fucose on epidermal growth factor-like (EGF) repeats of their extracellular domain to respond optimally to signal induction by canonical Notch ligands. Inactivation of the Golgi GDP-fucose transporter Slc35c1 in mouse or human does not cause marked defects in Notch signaling during development, and shows milder fucosylation defects than those observed in mice...

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Source

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Identifiers

PMID: 20837470
DOI: 10.1074/jbc.M110.126003
PMCID: PMC2975247

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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