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Article

P2Y2 Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling.

Circulation research - 10 Nov 2017

Khalafalla Farid G, Greene Steven, Khan Hashim, Ilves Kelli, Monsanto Megan M, Alvarez Roberto, Chavarria Monica, Nguyen Jonathan, Norman Benjamin, Dembitsky Walter P, Sussman Mark A

Abstract excerpt

RATIONALE: Autologous stem cell therapy using human c-Kit+ cardiac progenitor cells (hCPCs) is a promising therapeutic approach for treatment of heart failure (HF). However, hCPCs derived from aged patients with HF with genetic predispositions and comorbidities of chronic diseases exhibit poor proliferative and migratory capabilities, which impair overall reparative potential for injured myocardium. Therefore,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28923792
DOI: 10.1161/CIRCRESAHA.117.310812
PMCID: PMC5726767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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