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Article

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts.

ACS chemical biology - 20 Jan 2017

Paunovic Amalia I, Drowley Lauren, Nordqvist Anneli, Ericson Elke, Mouchet Elizabeth, Jonebring Anna, Grönberg Gunnar, Kvist Alexander J, Engkvist Ola, Brown Martin R, Gedda Karin, Goumans Marie-José, Wang Qing-Dong, Plowright Alleyn T

Abstract excerpt

Activation and proliferation of resident cardiac progenitor cells has therapeutic potential to repair the heart after injury. However, research has been impeded by a lack of well-defined and characterized cell sources and difficulties in translation to screening platforms. Here, we describe the development, validation, and use of a 384-well phenotypic assay in primary human epicardium-derived cells (EPDCs) to...

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PMID: 28103692
DOI: 10.1021/acschembio.6b00683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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