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Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth

11 Sept 2009

Abstract excerpt

RATIONALE: The adult heart possesses a pool of progenitor cells stored in myocardial niches, but the mechanisms involved in the activation of this cell compartment are currently unknown. OBJECTIVE: Ca2+ promotes cell growth raising the possibility that changes in intracellular Ca2+ initiate division of c-kit-positive human cardiac progenitor cells (hCPCs) and determine their fate. METHODS AND RESULTS: Ca2+...

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PMID: 19745162
DOI: 10.1161/circresaha.109.206698

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