Article
Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies.
Aging - 1 Jan 2015
Dmitrieva Renata I, Revittser Alla V, Klukina Maria A, Sviryaev Yuri V, Korostovtseva Ludmila S, Kostareva Anna A, Zaritskey Andrey Yu, Shlyakhto Evgeny V
Abstract excerpt
BACKGROUND: Bone marrow multipotent mesenchymal stromal cells (BM-MMSC) considered as a prospective substrate for cell therapy applications, however adult stem cells could be affected by donor-specific factors: age, gender, medical history. Our aim was to investigate how HF affects the functional properties of BM-MMSC. MATERIALS AND METHODS: BM-MMSC from 10 healthy donors (HD), and 16 donors with chronic HF were...
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