Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

doi:10.1093/jnci/djx121

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Article

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

Journal of the National Cancer Institute - 1 Jan 2018

Hanley Christopher J, Mellone Massimiliano, Ford Kirsty, Thirdborough Steve M, Mellows Toby, Frampton Steven J, Smith David M, Harden Elena, Szyndralewiez Cedric, Bullock Marc, Noble Fergus, Moutasim Karwan A, King Emma V, Vijayanand Pandurangan, Mirnezami Alex H, Underwood Timothy J, Ottensmeier Christian H, Thomas Gareth J

Abstract excerpt

Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential therapeutic targets. However, effective methods to manipulate these cells clinically have yet to be developed. Methods: CAF accumulation and prognostic significance in head and neck cancer (oral, n = 260; oropharyngeal, n = 271), and colorectal cancer...

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Identifiers

PMID: 28922779
DOI: 10.1093/jnci/djx121
PMCID: PMC5903651

Genes

NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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