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Article

NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis.

Oncogene - 1 Aug 2024

Wang Xinmiao, Zhao Hui, Luo Xinyue, Chen Yang, Shi Congyu, Wang Yifan, Bai Junqiang, Shao Zhe, Shang Zhengjun

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are known to promote angiogenesis in oral squamous cell carcinoma (OSCC). However, the epigenetic mechanisms through which CAFs facilitate angiogenesis within the tumor microenvironment are still poorly characterized. Nicotinamide N'-methyltransferase (NNMT), a member of the N-methyltransferase family, was found to be a key molecule in the activation of CAFs. This study shows...

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Topics

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Share to Cancer-Associated Fibroblasts
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Mouth Neoplasms

Share to Neovascularization, Pathologic

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Microenvironment

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 39069579
DOI: 10.1038/s41388-024-03112-2

Genes

NNMT
ETS2
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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