Article
Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel.
Brain research - 1 Dec 2017
Kuramoto Takashi, Yokoe Mayuko, Kunisawa Naofumi, Ohashi Kana, Miyake Takahito, Higuchi Yuki, Yoshimi Kazuto, Mashimo Tomoji, Tanaka Miyuu, Kuwamura Mitusru, Kaneko Shuji, Shimizu Saki, Serikawa Tadao, Ohno Yukihiro
Abstract excerpt
Tremor dominant Kyoto (Trdk) is an autosomal dominant mutation that appeared in F344/NSlc rats mutagenized with N-ethyl-N-nitrosourea (ENU). In this study, we characterized and genetically analyzed F344-Trdk/+ heterozygous rats. The rats exhibited a tremor that was especially evident around weaning but persisted throughout life. The tremors of F344-Trdk/+ rats were attenuated by drugs effective against essential...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.