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Article

A Drosophila Model of Essential Tremor.

Scientific reports - 16 May 2018

Smith Philip, Arias Ronald, Sonti Shilpa, Odgerel Zagaa, Santa-Maria Ismael, McCabe Brian D, Tsaneva-Atanasova Krasimira, Louis Elan D, Hodge James J L, Clark Lorraine N

Abstract excerpt

Essential Tremor (ET) is one of the most common neurological diseases, with an estimated 7 million affected individuals in the US; the pathophysiology of the disorder is poorly understood. Recently, we identified a mutation (KCNS2 (Kv9.2), c.1137 T > A, p.(D379E) in an electrically silent voltage-gated K+ channel α-subunit, Kv9.2, in a family with ET, that modulates the activity of Kv2 channels. We have produced...

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Identifiers

PMID: 29769701
DOI: 10.1038/s41598-018-25949-w
PMCID: PMC5955955

Genes

KCNS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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