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Article

Hcn1 Is a Tremorgenic Genetic Component in a Rat Model of Essential Tremor

13 May 2015

Abstract excerpt

Genetic factors are thought to play a major role in the etiology of essential tremor (ET); however, few genetic changes that induce ET have been identified to date. In the present study, to find genes responsible for the development of ET, we employed a rat model system consisting of a tremulous mutant strain, TRM/Kyo (TRM), and its substrain TRMR/Kyo (TRMR). The TRM rat is homozygous for the tremor (tm) mutation...

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PMID: 25970616
DOI: 10.1371/journal.pone.0123529

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