Article
Behavioral effects of a deletion in Kcnn2, the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channels.
Neurogenetics - 1 Oct 2008
Szatanik Marek, Vibert Nicolas, Vassias Isabelle, Guénet Jean-Louis, Eugène Daniel, de Waele Catherine, Jaubert Jean
Abstract excerpt
Small-conductance Ca(2+)-activated potassium (SK) channels are heteromeric complexes of SK alpha-subunits and calmodulin that modulate membrane excitability, are responsible for part of the after-hyperpolarization (AHP) following action potentials, and thus control the firing patterns and excitability of most central neurons. An engineered knockout allele for the SK2 subunit has previously been reported. The...
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