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Article

Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor.

Parkinsonism & related disorders - 1 May 2009

Sharkey Lisa M, Jones Julie M, Hedera Peter, Meisler Miriam H

Abstract excerpt

OBJECTIVES: Essential tremor (ET) is a common inherited movement disorder whose causes remain unknown. The presence of spontaneous tremor in murine mutants may provide clues into the pathogenesis of ET. SCN8A encodes the neuronal voltage gated sodium channel Na(v)1.6 that is widely expressed in the central nervous system. Several mutations of Scn8a in the mouse result in congenital postural tremor of the...

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Identifiers

PMID: 18718804
DOI: 10.1016/j.parkreldis.2008.06.010
PMCID: PMC2877193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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