Article
Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination.
Scientific reports - 15 Sept 2017
Korppi Matti, Teräsjärvi Johanna, Liehu-Martiskainen Milla, Lauhkonen Eero, Vuononvirta Juho, Nuolivirta Kirsi, Kröger Liisa, Pöyhönen Laura, Karjalainen Minna K, He Qiushui
Abstract excerpt
Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis...
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