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Potentiation and antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin effects in a complex environmental mixture.

Toxicology and applied pharmacology - 1 Apr 1993

Silkworth J B, Cutler D S, O'Keefe P W, Lipinskas T

Abstract excerpt

There is increasing need to understand the toxicity of complex environmental mixtures. The organic phase of a leachate (OPL) from the Love Canal chemical dump site is a complex mixture that contains over 100 organic compounds, including 0.74 ppm 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice congenic at the Ah locus were used to evaluate several toxic effects of the OPL, including immune function and hepatic...

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PMID: 8480332
DOI: 10.1006/taap.1993.1065

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