Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes.

Asian Pacific journal of cancer prevention : APJCP - 1 Sept 2025

Ibrahimov Akbar, Novruzova Fidan

Abstract excerpt

AIM: Mismatch repair (MMR) deficiency is a prognostic biomarker in multiple malignancies, but its clinical significance in ovarian cancer (OC) remains poorly defined. This study investigates the prevalence of MMR gene defects (MLH1, PMS2, MSH2, MSH6) across OC histotypes and their clinicopathological associations. METHODS: A retrospective cohort of 38 OC patients treated at Azerbaijan Medical University...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Recurrence, Local

Share to Ovarian Neoplasms

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 40952306
DOI: 10.31557/APJCP.2025.26.9.3477
PMCID: PMC12882017

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes.PMID 40952306Read ↗

Mismatch Repair Deficiency in Ovarian Carcinoma: Frequency, Causes, and Consequences.Semantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical ImplicationsSemantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Clinicopathologic characteristics and outcomes of endometrial Cancer patients with mismatch repair deficiency in the era of universal Lynch syndrome screening.Semantic proximity Read ↗

Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite InstabilitySemantic proximity Read ↗

Clinicopathologic significance of mismatch repair protein expression in endometrioid endometrial cancerSemantic proximity Read ↗

A review of the clinical relevance of mismatch‐repair deficiency in ovarian cancerSemantic proximity Read ↗

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read ↗

DNA Mismatch Repair–deficient Endometrial Carcinosarcomas Portend Distinct Clinical, Morphologic, and Molecular Features Compared With Traditional CarcinosarcomasSemantic proximity Read ↗

An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach.Semantic proximity Read ↗

Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.