Article
D-Dimer in African Americans: Whole Genome Sequence Analysis and Relationship to Cardiovascular Disease Risk in the Jackson Heart Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017
Raffield Laura M, Zakai Neil A, Duan Qing, Laurie Cecelia, Smith Joshua D, Irvin Marguerite R, Doyle Margaret F, Naik Rakhi P, Song Ci, Manichaikul Ani W, Liu Yongmei, Durda Peter, Rotter Jerome I, Jenny Nancy S, Rich Stephen S, Wilson James G, Johnson Andrew D, Correa Adolfo, Li Yun, Nickerson Deborah A, Rice Kenneth, Lange Ethan M, Cushman Mary, Lange Leslie A, Reiner Alex P
Abstract excerpt
OBJECTIVE: Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men. Among AAs, little is known of the genetic architecture of D-dimer or the relationship of D-dimer to incident cardiovascular disease. APPROACH AND RESULTS: We measured baseline D-dimer in 4163 AAs aged 21 to 93 years from...
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