Genome-Wide Association Study Identifies Protective Genetic Factors in Active Blood Donors Against Multiple Diseases

Abstract excerpt

The healthy donor effect (HDE) refers to the observed lower mortality rate among blood donors compared to the general population. While HDE arises due to healthier individuals being more likely to be able to donate, the extent to which it is influenced by genetic differences remains largely unclear. To elucidate the genetic basis of HDE, we conducted a genome-wide association study (GWAS) involving 53,688 active b...

Topics

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• ABO Blood-Group System
• Blood Donors
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide
• Reproducibility of Results
• Risk Factors

Identifiers and source

Literature Corpus work

fc14f3b1-0b60-51e1-a470-4f5361f7e733

DOI

10.1101/2024.06.18.24309089