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Article

Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015

Stratigi Kalliopi, Kapsetaki Manouela, Aivaliotis Michalis, Town Terrence, Flavell Richard A, Spilianakis Charalampos G

Abstract excerpt

Physiological processes rely on the regulation of total mRNA levels in a cell. In diploid organisms, the transcriptional activation of one or both alleles of a gene may involve trans-allelic interactions that provide a tight spatial and temporal level of gene expression regulation. The mechanisms underlying such interactions still remain poorly understood. Here, we demonstrate that lipopolysaccharide stimulation...

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Identifiers

PMID: 25770217
DOI: 10.1073/pnas.1502182112
PMCID: PMC4386343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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