Article
Redundant and incoherent regulations of multiple phenotypes suggest microRNAs' role in stability control.
Genome research - 1 Oct 2017
Liufu Zhongqi, Zhao Yixin, Guo Li, Miao Guangxia, Xiao Juan, Lyu Yang, Chen Yuxin, Shi Suhua, Tang Tian, Wu Chung-I
Abstract excerpt
Each microRNA (miRNA) represses a web of target genes and, through them, controls multiple phenotypes. The difficulties inherent in such controls cast doubt on how effective miRNAs are in driving phenotypic changes. A "simple regulation" model posits "one target-one phenotype" control under which most targeting is nonfunctional. In an alternative "coordinate regulation" model, multiple targets are assumed to...
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