Alternate routes to mnm ⁵ s ² U synthesis in Gram-positive bacteria

Abstract excerpt

The wobble bases of tRNAs that decode split codons are often heavily modified. In Bacteria tRNA Glu, Gln, Asp contain a variety of xnm 5 s 2 U derivatives. The synthesis pathway for these modifications is complex and fully elucidated only in a handful of organisms, including the Gram-negative Escherichia coli K12 model. Despite the ubiquitous presence of mnm 5 s 2 U modification, genomic analysis shows the a...

Topics

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• Bacillaceae
• Methyltransferases
• Mutation
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• RNA, Transfer
• RNA, Transfer, Leu
• tRNA Methyltransferases

Identifiers and source

Literature Corpus work

30ae921c-29b1-5234-bbf7-fc10834cdc6e

DOI

10.1101/2023.12.21.572861