Article
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
Nature communications - 12 Sept 2017
Chang Chia-Jung, Chen Chien-Hsiun, Chen Bing-Mae, Su Yu-Cheng, Chen Ying-Ting, Hershfield Michael S, Lee Ming-Ta Michael, Cheng Tian-Lu, Chen Yuan-Tsong, Roffler Steve R, Wu Jer-Yuarn
Abstract excerpt
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some healthy individuals have pre-existing anti-PEG antibodies and certain patients develop anti-PEG antibody during treatment with PEGylated medicines, suggesting that genetics might play a role in PEG immunogenicity. Here we perform genome-wide association studies for anti-PEG IgM and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.