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Article

Site-directed pegylation of recombinant interleukin-2 at its glycosylation site.

Bio/technology (Nature Publishing Company) - 1 Apr 1990

Goodson R J, Katre N V

Abstract excerpt

We have modified recombinant interleukin-2 (rIL-2) to facilitate site-directed covalent attachment of monomethoxy polyethylene glycol (PEG). The site chosen for modification and subsequent covalent attachment with PEG (PEGylation) was the single glycosylation position found in the native interleukin-2 (IL-2). The mutant protein was expressed in E. coli, purified, and PEGylated with a PEG-maleimide reagent to...

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PMID: 1366535
DOI: 10.1038/nbt0490-343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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