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Article

Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics.

Chemico-biological interactions - 6 Sept 2010

Kronman Chanoch, Cohen Ofer, Mazor Ohad, Ordentlich Arie, Raveh Lily, Velan Baruch, Shafferman Avigdor

Abstract excerpt

We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. By profiling the pharmacokinetic behavior of an array of well-defined hypo...

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Identifiers

PMID: 20005217
DOI: 10.1016/j.cbi.2009.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20005217-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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