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Article

A novel high-throughput screening method for microbial transglutaminases with high specificity toward Gln141 of human growth hormone.

Journal of biomolecular screening - 1 Feb 2010

Zhao Xin, Shaw Allan C, Wang Jianhua, Chang Chih-Chuan, Deng Jianhui, Su Jing

Abstract excerpt

PEGylation modification has been used to improve the pharmacokinetic properties of protein-based drugs. For example, PEGylated human growth hormone (hGH) has been shown to exhibit better pharmacokinetic profiles than the unmodified hGH. Unlike chemical PEGylation of hGH that is difficult to be controlled to result in homogeneity, microbial transglutaminase (mTGase) only conjugates poly(ethelene glycol) (PEG) on...

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PMID: 20086216
DOI: 10.1177/1087057109356206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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