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Article

PEGylation and antioxidant effects of a human glutathione peroxidase 1 mutant.

Aging - 12 Jan 2022

Zhang Guang-Yuan, Wang Yan-Wei, Guo Li-Ying, Lin Liang-Ru, Niu Shao-Peng, Xiong Chang-Hao, Wei Jing-Yan

Abstract excerpt

Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hGPx1 have affected its development and application. To solve this problem, we prepared a hGPx1 mutant (GPx1M) with high activity in an Escherichia coli BL21(DE3)cys auxotrophic strain using a single protein production (SPP) system. In this study, the GPx1M was conjugated with...

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Identifiers

PMID: 35020600
DOI: 10.18632/aging.203822
PMCID: PMC8791217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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