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Article

Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells.

Science signaling - 12 Sept 2017

Mehta Anita K, Hua Kevin, Whipple William, Nguyen Minh-Thuy, Liu Ching-Ti, Haybaeck Johannes, Weidhaas Joanne, Settleman Jeff, Singh Anurag

Abstract excerpt

KRAS mutant non-small cell lung cancer (NSCLC) may be classified into epithelial or mesenchymal subtypes. Despite having the same "driver" mutation, mesenchymal NSCLCs are less responsive than are epithelial NSCLCs to inhibition of the RAS pathway. Identifying alternative networks that promote survival specifically in mesenchymal NSCLC may lead to more effective treatments for this subtype. Through their numerous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28900044
DOI: 10.1126/scisignal.aam6291
PMCID: PMC5657393

Genes

KRAS
BECN1
TRAF6
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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