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Article

The sp7 gene is required for maturation of osteoblast-lineage cells in medaka (Oryzias latipes) vertebral column development.

Developmental biology - 15 Nov 2017

Azetsu Yuki, Inohaya Keiji, Takano Yoshiro, Kinoshita Masato, Tasaki Mai, Kudo Akira

Abstract excerpt

Sp7 is a zinc finger transcription factor that is essential for osteoblast differentiation in mammals. To verify the characteristic features of osteoblast-lineage cells in teleosts, we established medaka sp7 mutants using a transcription activator-like effector nuclease (TALEN) genome editing system. These mutants showed severe defects in the formation of skeletal structures. In particular, the neural and the...

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PMID: 28899668
DOI: 10.1016/j.ydbio.2017.09.010

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