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Article

Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts

5 Feb 2018

Abstract excerpt

The Sp7/Osterix transcription factor is essential for bone development. Mutations of the Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta. However, the role of Sp7 in embryonic tooth development remains unknown. Here we identified the functional requirement of Sp7 for dentin synthesis and tooth development. Sp7-null mice exhibit craniofacial dysmorphogenesis and are...

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PMID: 29405385
DOI: 10.1002/jbmr.3401

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Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and OdontoblastsPMID 29405385Read ↗

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