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Article

Japanese medaka Olpax6.1 mutant as a potential model for spondylo-ocular syndrome.

Functional & integrative genomics - 19 May 2023

Pan Qihua, Lu Ke, Luo Junzhi, Jiang Yuewen, Xia Bilin, Chen Lei, Wang Mengyang, Dai Ronggui, Chen Tiansheng

Abstract excerpt

pax6 is a canonic master gene for eye formation. Knockout of pax6 affects the development of craniofacial skeleton and eye in mice. Whether pax6 affects the development of spinal bone has not been reported yet. In the present study, we used CRISPR/Cas9 system to generate Olpax6.1 mutant in Japanese medaka. Phenotype analysis showed that ocular mutation caused by the Olpax6.1 mutation occurred in the homozygous...

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PMID: 37204625
DOI: 10.1007/s10142-023-01090-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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