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Article

Moderate forced running exercise induces cartilage adaptation but exacerbates the molecular cartilage phenotype of type IX collagen knockout mice.

American journal of physiology. Cell physiology - 1 Jun 2026

Weyers Miriam, Li Thomas, Dreiner Maren, Mählich Daniela, Lorenz Charlotte, de Roy Luisa, Zigrino Paola, Han Lin, Brachvogel Bent, Zaucke Frank, Niehoff Anja

Abstract excerpt

Mechanical loading is essential for the assembly and maintenance of the articular cartilage extracellular matrix (ECM), whereas alterations in ECM composition profoundly affect cartilage mechanics and function. Type IX collagen is a heterotrimeric fibril-associated collagen with interrupted triple helices (FACIT) that is covalently linked to type II collagen. It restricts lateral fibril growth and mediates...

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Share to Cartilage, Articular
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42154996
DOI: 10.1152/ajpcell.00959.2025

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COMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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