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The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions

6 Nov 2020

Abstract excerpt

Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a population of self-renewing, therapeutically resistant cancer stem cells (CSCs). Glioblastoma (GBM), the most common primary malignant brain tumor, has served as a platform for the study of CSCs. In addition to illustrating the complexities of CSC biology, these investigations have led to a deeper understanding of GBM...

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PMID: 33173943
DOI: 10.1093/neuonc/noaa259

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