Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?

Abstract excerpt

By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to...

Topics

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• Disease Progression
• Ecosystem
• Mutation
• Neoplasms
• Tumor Microenvironment