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PEA-15 Induces Autophagy in Human Ovarian Cancer Cells and Is Associated with Prolonged Overall Survival

14 Nov 2008

Abstract excerpt

Phospho-enriched protein in astrocytes (PEA-15) is a 15-kDa phosphoprotein that slows cell proliferation by binding to and sequestering extracellular signal-regulated kinase (ERK) in the cytoplasm, thereby inhibiting ERK-dependent transcription and proliferation. In previous studies of E1A human gene therapy for ovarian cancer, we discovered that PEA-15 induced the antitumor effect of E1A by sequestering...

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PMID: 19010903
DOI: 10.1158/0008-5472.can-08-2592

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PEA-15 Induces Autophagy in Human Ovarian Cancer Cells and Is Associated with Prolonged Overall SurvivalPMID 19010903Read ↗

PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-cateninSemantic proximity Read ↗

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Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei.Semantic proximity Read ↗

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