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Article

The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells.

The Journal of experimental medicine - 18 Jan 2010

Casartelli Nicoletta, Guivel-Benhassine Florence, Bouziat Romain, Brandler Samantha, Schwartz Olivier, Moris Arnaud

Abstract excerpt

The cytidine deaminase APOBEC3G (A3G) enzyme exerts an intrinsic anti-human immunodeficiency virus (HIV) defense by introducing lethal G-to-A hypermutations in the viral genome. The HIV-1 viral infectivity factor (Vif) protein triggers degradation of A3G and counteracts this antiviral effect. The impact of A3G on the adaptive cellular immune response has not been characterized. We examined whether A3G-edited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20038599
DOI: 10.1084/jem.20091933
PMCID: PMC2812543

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