The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.

doi:10.1016/j.rbmo.2017.07.007

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Article

The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.

Reproductive biomedicine online - 1 Nov 2017

Qin Chunrong, Chen Yong, Lin Qing, Yao Jilong, Wu Weiqing, Xie Jiansheng

Abstract excerpt

The aim of this study was to investigate whether polymorphism and expression of CYP17, CYP1A1, COMT and SULT1A1 affected the risk of idiopathic primary ovarian insufficiency (POI) in Chinese women. DNA sequencing and real-time PCR were used to detect these genes in 132 cases of idiopathic POI and 132 normal women. A significant increase in the C allele of CYP17 (rs743572) polymorphism was observed in women with...

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PMID: 28887105
DOI: 10.1016/j.rbmo.2017.07.007

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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