COMT polymorphism influences decrease of ovarian follicles and emerges as a predictive factor for premature ovarian insufficiency.

doi:10.1186/1757-2215-7-47

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Article

COMT polymorphism influences decrease of ovarian follicles and emerges as a predictive factor for premature ovarian insufficiency.

Journal of ovarian research - 1 Jan 2014

Cordts Emerson Barchi, Santos Monise Castro, Peluso Carla, Kayaki Erika Azuma, Bianco Bianca, Barbosa Caio Parente, Christofolini Denise Maria

Abstract excerpt

BACKGROUND: Estrogens are important factors in the female reproductive functions and are processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes a crucial element in estrogen metabolism and is assumed to be involved in the development of Premature Ovarian Insufficiency (POI). This study aimed to determine whether the presence of the COMT Val/Met polymorphism (rs4680) is...

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Identifiers

PMID: 24808926
DOI: 10.1186/1757-2215-7-47
PMCID: PMC4012167

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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