Article
A multicenter case-control study on screening of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in han chinese.
Gynecologic and obstetric investigation - 1 Jan 2014
Shen Yang, Ren Mu-Lan, Xu Jie, Xu Qian, Ding Yi-Qian, Wu Zhi-Cong, Zhang Hai-Bao, Huang Xian-Xia, Cai Yun-Lang
Abstract excerpt
Uterine leiomyoma (UL) is an estrogen-responsive benign tumor in the female reproductive system and the main risk of hysterectomy for women. However, gene polymorphism of estrogen-metabolizing enzymes may lead to the different susceptibility to UL. We detected 10 single mucleotide polymorphisms in three key estrogen metabolite enzymes (COMT, CYP1A1, CYP1B1) in a Chinese Han population consisting of 800 patients...
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