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Article

Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.

PloS one - 1 Jan 2021

Ikeda Keiko, Tienda Adriana A, Harrison Fiona E, Kawakami Kiyoshi

Abstract excerpt

Na+,K+-ATPase is a crucial protein responsible for maintaining the electrochemical gradients across the cell membrane. The Na+,K+-ATPase is comprised of catalytic α, β, and γ subunits. In adult brains, the α3 subunit, encoded by ATP1A3, is predominantly expressed in neurons, whereas the α2 subunit, encoded by ATP1A2, is expressed in glial cells. In foetal brains, the α2 is expressed in neurons as well. Mutations...

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Source

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Identifiers

PMID: 33544780
DOI: 10.1371/journal.pone.0246678
PMCID: PMC7864419

Genes

ATP1A2
ATP1A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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