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Article

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.

Molecular cell - 7 Sept 2017

Shinohara Yuta, Koyama Yohei M, Ukai-Tadenuma Maki, Hirokawa Takatsugu, Kikuchi Masaki, Yamada Rikuhiro G, Ukai Hideki, Fujishima Hiroshi, Umehara Takashi, Tainaka Kazuki, Ueda Hiroki R

Abstract excerpt

Temperature compensation is a striking feature of the circadian clock. Here we investigate biochemical mechanisms underlying temperature-compensated, CKIδ-dependent multi-site phosphorylation in mammals. We identify two mechanisms for temperature-insensitive phosphorylation at higher temperature: lower substrate affinity to CKIδ-ATP complex and higher product affinity to CKIδ-ADP complex. Inhibitor screening of...

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Identifiers

PMID: 28886336
DOI: 10.1016/j.molcel.2017.08.009

Genes

TTBK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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