Article
Crystal structure of E. coli apolipoprotein N-acyl transferase.
Nature communications - 4 Jul 2017
Lu Guangyuan, Xu Yingzhi, Zhang Kai, Xiong Yong, Li He, Cui Lei, Wang Xianping, Lou Jizhong, Zhai Yujia, Sun Fei, Zhang Xuejun C
Abstract excerpt
In Gram-negative bacteria, lipid modification of proteins is catalysed in a three-step pathway. Apolipoprotein N-acyl transferase (Lnt) catalyses the third step in this pathway, whereby it transfers an acyl chain from a phospholipid to the amine group of the N-terminal cysteine residue of the apolipoprotein. Here, we report the 2.6-Å crystal structure of Escherichia coli Lnt. This enzyme contains an exo-membrane...
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