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Article

Structural basis of lantibiotic recognition by the nisin resistance protein from Streptococcus agalactiae.

Scientific reports - 4 Jan 2016

Khosa Sakshi, Frieg Benedikt, Mulnaes Daniel, Kleinschrodt Diana, Hoeppner Astrid, Gohlke Holger, Smits Sander H J

Abstract excerpt

Lantibiotics are potent antimicrobial peptides. Nisin is the most prominent member and contains five crucial lanthionine rings. Some clinically relevant bacteria express membrane-associated resistance proteins that proteolytically inactivate nisin. However, substrate recognition and specificity of these proteins is unknown. Here, we report the first three-dimensional structure of a nisin resistance protein from...

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Identifiers

PMID: 26727488
DOI: 10.1038/srep18679
PMCID: PMC4698656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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