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Article

Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility.

Scientific reports - 29 Apr 2016

Xu Zhongli, von Grafenstein Susanne, Walther Elisabeth, Fuchs Julian E, Liedl Klaus R, Sauerbrei Andreas, Schmidtke Michaela

Abstract excerpt

Streptococcus pneumoniae is the leading pathogen causing bacterial pneumonia and meningitis. Its surface-associated virulence factor neuraminidase A (NanA) promotes the bacterial colonization by removing the terminal sialyl residues from glycoconjugates on eukaryotic cell surface. The predominant role of NanA in the pathogenesis of pneumococci renders it an attractive target for therapeutic intervention. Despite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27125351
DOI: 10.1038/srep25169
PMCID: PMC4850393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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