Article
The Association of HLA-E Ligand and NKG2 Receptor Variation With Relapse and Mortality After Haploidentical Related Donor Transplantation.
Transplantation and cellular therapy - 1 Mar 2025
Petersdorf Effie W, McKallor Caroline, Malkki Mari, Hsu Katherine, He Meilun, Spellman Stephen R, Gooley Theodore, Stevenson Philip
Abstract excerpt
BACKGROUND: Recurrence of blood malignancy is the major cause of mortality after hematopoietic cell transplantation. NKG2 receptor/HLA-E ligand complexes play a fundamental role in the surveillance and elimination of transformed cells but their role in the control of leukemia in transplantation is unknown. OBJECTIVE: We tested the hypothesis that gene variation of patient and/or donor HLA-E ligand and donor...
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